Research Areas > Circulatory Vascular Flows and Biomedical Imaging

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Development of hybrid bright-hologram imaging system

Post Image  Light scattering pattern from ellipsoidal particle is reconstructed using digital holographic microscopy. 3D orientation of ellipsoidal particle, which is essential for 3D dynamics analysis, can be measured.   내용 보기

Application of phase-contract holographic microscopy on red blood cell

Post Image  Common-path type phase contrast holographic microscopy is able to obtain phase information with nanometer scale order. Fluctuations in RBC membrane were measured to obtain shear modulus of membrane. Effects of malaria infection and drug on RBCs were measured using this technique.   내용 보기

RBC classification using digital holographic microscopy and machine learning algorithms

Post Image   Cell types of erythrocytes should be identified because they are closely related to their functionality and viability. In this study, we proposed a new label-free sensor for automatic identification of erythrocyte cell types using a digital in-line holographic microscopy (DIHM) combined with machine learning algorithms. A total of 12 features is quantitatively obtained from numerically reconstructed holographic images. With the aid of these machine learning algorithms, the extracted features are effectively utilized to distinguish erythrocytes. Among the four tested algorithms, ...   내용 보기

Enhancement of measurement accuracy of X-ray PIV in comparison with micro PIV technique

Post Image  X-ray PIV technique has been used as a non-invasive measurement modality to investigate the hemodynamic features of blood flow. However, the extraction of 2D velocity field data from the 3D volumetric information contained in X-ray images is technically unclear. In this study, we propose a new 2D velocity field extraction technique to overcome technological limitations.  To resolve with the problem of finding correction coefficient, the velocity field information obtained by X-ray PIV and micro PIV techniques for disturbed flow in a concentric stenosis with 50% severity ...   내용 보기

Effective method for drug injection into subcutaneous tissue

Post Image  Subcutaneous injection of drug solution is widely used for continuous and low dose drug treatment. Although the drug injections have been administered for a long time, challenges in the design of injection devices are still needed to minimize the variability, pain, or skin disorder by repeated drug injections. To avoid these adverse effects, systematic study on the effects of injection conditions should be conducted to improve the predictability of drug effect. Here, the effects of injection conditions on the drug diffusion in tissues were investigated using X-ray imaging techniq...   내용 보기

In vivo measurement of hemodynamic information in stenosed rat blood vessels using X-ray PIV

Post Image  3D clips fabricated with a 3D printer were applied to the abdominal aorta of a rat cadaver to induce artificial stenosis in the real blood vessel of an animal model. The velocity and WSS information of blood flows in the stenosed vessel were obtained and compared at various stenosis severities. In vivo measurement was also conducted by fastening a stenotic clip on a live rat model through surgical intervention to reduce the flow rate to match the limited temporal resolution of the present X-ray PIV system. Further improvement of the temporal resolution of the system might be able...   내용 보기

Flow characteristics around a deformable stenosis

Post Image  The effect of stenotic deformation on the flow characteristics of the deformable stenosis was investigated experimentally under pulsatile flow condition. The phasic shape variation enhances the increasing rate of the jet velocity, which in turn causes the high increasing rate of the TKE production rate as compared with that in rigid stenosis models. This phenomenon induces the phase delay of the peak position in the waveform related with the pressure drop across the stenosis.   내용 보기

Label-free sensing and classification of old stored blood

Post Image  H-shaped microfluidic device and digital in-line holographic microscopy were employed to measure temporal variations of blood viscosity and the optical focusing property of erythrocytes during blood storage. New criteria for depository period of stored blood and indexes (viscosity and focal length of erythrocytes) were proposed to determine its appropriateness for transfusion.   내용 보기

Enhancement of measurement accuracy of X-ray PIV in comparison with micro PIV technique

Post Image  X-ray PIV technique has been used as a non-invasive measurement modality to investigate the hemodynamic features of blood flow. However, the extraction of 2D velocity field data from the 3D volumetric information contained in X-ray images is technically unclear. In this study, we propose a new 2D velocity field extraction technique to overcome technological limitations.   To resolve with the problem of finding correction coefficient, the velocity field information obtained by X-ray PIV and micro PIV techniques for disturbed flow in a concentric stenosis with 50% severity...   내용 보기

Effective method for drug injection into subcutaneous tissue

Post Image  Subcutaneous injection of drug solution is widely used for continuous and low dose drug treatment. Although the drug injections have been administered for a long time, challenges in the design of injection devices are still needed to minimize the variability, pain, or skin disorder by repeated drug injections. To avoid these adverse effects, systematic study on the effects of injection conditions should be conducted to improve the predictability of drug effect. Here, the effects of injection conditions on the drug diffusion in tissues were investigated using X-ray imaging techniq...   내용 보기